The ranges and research cited on this page are for informational purposes only and do not constitute medical advice. Always consult a qualified healthcare provider.

Science Reference

Every Biomarker.
Every Range. Every Reason.

Lab reference ranges define what's statistically common. Aere defines what's actually optimal — ranges derived from the research that predicts who lives longest and healthiest.

143
Biomarkers
304+
Citations
23
Categories

Our Philosophy

“Normal” is not the same as optimal.

Standard lab reference ranges represent the middle 95% of a population that includes sedentary, metabolically unhealthy, and aging individuals. A result within range means you are not an outlier in a sick population — nothing more.

Aere defines optimal ranges from prospective cohort studies, intervention trials, and mechanistic research — the levels associated with the lowest disease risk and longest healthspan.

Evidence-first
Every optimal range cites peer-reviewed research. Confidence levels reflect the quality and consistency of the underlying evidence — strong, moderate, or emerging.
Longevity-oriented
We prioritize studies measuring long-term outcomes — all-cause mortality, cardiovascular events, cognitive decline — not just absence of clinical diagnosis.
Individually contextualized
Sex-specific ranges, age-adjusted norms, and population differences are incorporated where the evidence supports them rather than applying averaged reference ranges.

Methodology

How we set optimal ranges

A consistent process applied to every biomarker in the reference.

1
Source hierarchy
Peer-reviewed meta-analyses and large prospective cohorts (NEJM, JAMA, Lancet, BMJ) take precedence. Clinical guidelines (ACC/AHA, KDIGO, ADA, IFM) and expert longevity physicians (Attia, Patrick, Longo) inform gaps where RCT data is limited.
2
Confidence tiers
Strong — consistent evidence across multiple large studies or randomized trials. Moderate — single high-quality study or consistent smaller trials. Emerging — mechanistic rationale with limited direct human outcome data.
3
Sex-specific ranges
Where physiology differs (CBC, hormones, iron studies, lipid fractions), Aere applies sex-specific optimal ranges grounded in sex-stratified data, not population averages that mask meaningful biological differences.

Biomarker Reference

143 biomarkers, explained

Search by name or alias. Filter by category. Click any biomarker to read the evidence.

143 biomarkers

Medical disclaimer: This reference is for educational purposes only and does not constitute medical advice. Optimal ranges are intended to inform conversations with your healthcare provider, not replace clinical judgment. Individual variation, medications, and health conditions significantly affect biomarker interpretation. Always consult a qualified physician before making health decisions based on lab results.